joyces@arizona.edu(link sends e-mail)
Professor in MCB
Hometown: Phoenix, AZ
Alma Maters: University of Arizona, Mayo Clinic - Scottsdale, University of North Carolina - Chapel Hill
My interest in studying cancer began as a graduate student at the University of North Carolina, Chapel Hill where I was studying microbiology and immunology. I became fascinated with the biology of cancer – a disease of self, created by cellular changes that allowed for tumors to wreak havoc and devastation on an otherwise healthy individual. As a student in the laboratory of David Lee, Ph.D., I gained expertise in the expression and function of the Epidermal Growth Factor Receptor, as well as the use of the mouse as a model for the complex interplay between cells and their environment in the developing mammary gland. After graduation, I went to the laboratory of Sandra Gendler, Ph.D., at the Mayo Clinic in Scottsdale, to perform a postdoctoral fellowship that focused on the expression and function of MUC1 in breast cancer. Since coming to the University of Arizona in 2002, my lab has continued to work on understanding the molecular mediators of breast cancer, using these discoveries to design novel cancer therapeutics. Our ultimate goal is to understand the underpinnings of cancer development and progression and to design tumor-specific drugs that block those activities.
Publications:
POST DOCTORAL RESEARCH
Schroeder JA, Al Masri A, Adriance MC, Tessier JC, Kotlarczyk KL, Thompson MC, Gendler SJ. (2004) Sustained alveolar differentiation accompanies MUC1-induced mammary gland carcinoma and metastasis. Oncogene. 23:5739-47.
Hattrup CL, Fernandez-Rodriguez J, Schroeder JA, Hansson GC, Gendler SJ. (2004)MUC1 can interact with adenomatous polyposis coli in breast cancer. Biochemical and Biophysical Research Communications. 316:364-369.
Schroeder JA, Adriance MC, Thompson MC, Camenisch TD, Gendler SJ. (2003) MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion. Oncogene. 22:1324-1332.
Schroeder JA, Jackson L, Lee DC, Camenisch TD. (2003) Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling. Journal of Molecular Medicine. 81:392-403.
Camenisch TD, Schroeder JA, Bradley J, McDonald JA. (2002)Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. Nature Medicine. 8:850-855.
Schroeder* JA, Adriance* MC, McConnell EG, Thompson MC, Pckaj BA, Gendler SJ. (2002) ErbB/beta-catenin complexes are associated with human infiltrating ductal breast and MMTV-Wnt-1 and MMTV-c-neu transgenic carcinomas. Journal of Biological Chemistry. 277:22692-22698.
Schroeder JA, Thompson M, Gardner M, Gendler SJ. (2001) Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. Journal of Biological Chemistry. 276:13057-13064.
GRADUATE SCHOOL
Schroeder JA, Troyer K, Lee DC. (2000)Cooperative induction of mammary tumorigenesis by TGFalpha and Wnts. Oncogene. 19:3193-3199.
Schroeder JA, Lee DC. (1998) Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland. Cell Growth and Differentiation (cover). 9:451-464.
Schroeder JA, Lee DC. (1997) Transgenic mice reveal roles for TGFalpha and EGF receptor in mammary gland development and neoplasia. Journal of Mammary Gland Biology Neoplasia. 2:119-129.
Berkowitz A, Seroogy KB, Schroeder JA, Russell WE, Evans EP, Riedel RF, Phillips HK, Harrison CA, Lee DC, Luetteke NC. (1996) Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues. Cell Growth and Differentiation. 7:1271-1282.
Sandgren EP, Schroeder JA, Qiu TH, Palmiter RD, Brinster RL, Lee DC. (1995) Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice.Cancer Research. 55:3915-3927.
UNDERGRADUATE
Schluter SF, Schroeder JA, Wang E, Marchalonis JJ. (1994) Recognition molecules and immunoglobulin domains in invertebrates. Proc. New York Acad. Sci. 712-74-81.
Akins JM, Schroeder JA, Brower DL, Aposhian HV. (1992) Evaluation of Drosophila melanogaster as an alternative animal for studying the neurotoxicity of heavy metals. Biometals. 5:111-120.